Some antibodies coat the harmful organisms so that the body's scavenger cells can recognize and destroy them more easily.
During periods of active antibody production, lymph nodes often enlarge and become tender to the touch.
For example, a vaccination (injection of a natural or artificial antigen to stimulate the body to produce protective antibodies) in the arm can cause swelling of the nodes in the armpit, while mononucleosis causes enlargement of nodes that can be felt under the skin of the armpits, groin, and neck. The spleen (an organ located in the upper left part of the abdomen) is also important in the production of antibodies.